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Myristoyl Pentapeptide-17
A lipopeptide used in cosmetic products to promote eyelash and eyebrow growth by stimulating keratin production in hair follicles.
Overview
Myristoyl Pentapeptide-17 is a synthetic lipopeptide consisting of five amino acids attached to a myristic acid chain. It was specifically developed for use in eyelash and eyebrow enhancing products, where it works by stimulating keratin gene expression in hair follicle cells. Keratin is the primary structural protein of hair, and by upregulating its production, the peptide aims to promote thicker, longer, and healthier lash and brow growth.
The myristic acid moiety serves to improve the peptide's penetration into the skin and hair follicle. This lipid conjugation allows the molecule to cross the stratum corneum more effectively and reach the dermal papilla and matrix cells of the hair follicle where keratin synthesis occurs. The specific peptide sequence was designed to interact with cellular pathways involved in keratin gene regulation.
In vitro studies have demonstrated that Myristoyl Pentapeptide-17 can increase keratin protein expression in cultured keratinocytes. The upregulation of keratin synthesis is believed to translate into improved hair shaft thickness and strength. Some manufacturers have also reported clinical data showing increased lash length and density with products containing this peptide, though independent peer-reviewed studies remain limited.
This peptide is commonly found in lash serums, brow enhancers, and mascara products that claim to provide conditioning and growth-stimulating benefits. It is often combined with other lash-enhancing ingredients such as biotin, panthenol, and other peptides to create comprehensive lash and brow treatment products.